TiO2 hollow nanosphere (HNS) are prepared via NaCl templates in a one-pot approach. The NaCl templates are realized by solvent/anti-solvent strategies and coated with TiO2via controlled hydrolysis of Ti-alkoxides. The NaCl template can be easily removed by washing with water, and the TiO2 HNS are finally impregnated with Pd/Pt. Electron microscopy shows TiO2 HNS with an outer diameter of 140-180 nm, an inner cavity of 80-100 nm, and a wall thickness of 30-40 nm. The TiO2 HNS exhibit high surface area (up to 370 m2 g-1) and pore volume (up to 0.28 cm3 g-1) with well-distributed small Pd/Pt nanoparticles (Pt: 3-4 nm, Pd: 3-7 nm). H2O2 direct synthesis (room temperature, liquid phase) and CO oxidation (up to 300 °C, gas phase) are used to probe the catalytic properties and result in a good stability of the HNS structure as well as a promising performance with a H2O2 selectivity of 63% and a productivity of 3390 mol kgPd-1 h-1 (TiO2-Pd HNS, 5 wt%) as well as CO oxidation light-out temperatures of 150 °C (TiO2-Pt HNS, 0.7 wt%).