Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Enhances Adaptive Immunity to C difficile Toxin B

Gastroenterology. 2021 May;160(6):2155-2158.e4. doi: 10.1053/j.gastro.2021.01.009. Epub 2021 Jan 11.
No abstract available

Keywords: Antigen-specific; C difficile; CD4 T cell; Fecal Microbiota Transplant; T cell receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Proteins / immunology*
  • Bacterial Toxins / immunology*
  • Clostridioides difficile*
  • Enterocolitis, Pseudomembranous / therapy*
  • Enterotoxins / immunology
  • Fecal Microbiota Transplantation*
  • Female
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Interleukin-17 / metabolism
  • Interleukin-22
  • Interleukins / metabolism
  • Male
  • Middle Aged
  • Receptors, Antigen, T-Cell / metabolism
  • Recurrence
  • Th17 Cells* / metabolism
  • Th2 Cells
  • Young Adult

Substances

  • Bacterial Proteins
  • Bacterial Toxins
  • Enterotoxins
  • IL17A protein, human
  • Immunoglobulin A
  • Immunoglobulin G
  • Interleukin-17
  • Interleukins
  • Receptors, Antigen, T-Cell
  • tcdA protein, Clostridium difficile
  • toxB protein, Clostridium difficile