Generation of HBsAg-reactive T- and B-cells following HBV vaccination in serological non-responders under hemodialysis treatment

Toralf Roch; Claudia Giesecke-Thiel; Arturo Blazquez-Navarro; Patrizia Wehler; Constantin J Thieme; Kerstin Juelke; Gerald Grütz; Jan Hörstrup; Oliver Witzke; Ulf Dittmer; Ulrik Stervbo; Petra Reinke; Timm H Westhoff; Nina Babel

doi:10.1002/eji.202048756

Generation of HBsAg-reactive T- and B-cells following HBV vaccination in serological non-responders under hemodialysis treatment

Eur J Immunol. 2021 May;51(5):1278-1281. doi: 10.1002/eji.202048756. Epub 2021 Feb 9.

Authors

Toralf Roch^{1

2}, Claudia Giesecke-Thiel^{3

4}, Arturo Blazquez-Navarro^{1

2}, Patrizia Wehler^{1

2}, Constantin J Thieme², Kerstin Juelke⁵, Gerald Grütz⁵, Jan Hörstrup⁶, Oliver Witzke⁷, Ulf Dittmer⁸, Ulrik Stervbo², Petra Reinke^{1

9}, Timm H Westhoff², Nina Babel^{1

2}

Affiliations

¹ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
² Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.
³ Max Planck Institute for Molecular Genetics, Berlin, Germany.
⁴ Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany.
⁵ BIH Center for Regenerative Therapies (BCRT) Charité - Universitätsmedizin Berlin Inst. f. Med. Immunologie Immunologisches Studienlabor (ISL) - Biomarker, Germany.
⁶ KfH Nierenzentrum Berlin-Charlottenburg, Berlin, Germany.
⁷ Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Germany.
⁸ Institute for Virology, Universitätsklinikum of University Duisburg-Essen, Essen, Germany.
⁹ Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

PMID: 33459347
DOI: 10.1002/eji.202048756

Abstract

HBV vaccination is recommend for hemodialysis patients, but only 50-60% of the patients show seroconversion. HBV vaccine-induced generation of HBV reactive T and B cells could be detected regardless of their capacity to mount a serological response, indicating that patients without seroconversion are potentially protected by their HBV-reactive T cell pool.

Keywords: T cells; anti-HBsAg titer; antigen-specific B cells; hepatitis B virus; renal diseases.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

B-Lymphocytes / immunology*
B-Lymphocytes / metabolism
Biomarkers
Cytokines / metabolism
Hepatitis B Antibodies / immunology
Hepatitis B Surface Antigens / immunology*
Hepatitis B Vaccines / administration & dosage
Hepatitis B Vaccines / immunology
Hepatitis B virus / immunology*
Humans
Immunophenotyping
Lymphocyte Activation / immunology*
Renal Dialysis
T-Lymphocytes / immunology*
T-Lymphocytes / metabolism
Vaccination

Substances

Biomarkers
Cytokines
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B Vaccines