New aureolic acid antibiotics. I. Screening, isolation, characterization and biological properties

J Antibiot (Tokyo). 1988 Jan;41(1):45-52. doi: 10.7164/antibiotics.41.45.

Abstract

A new antibiotic complex was isolated from the fermentation broth of Streptomyces aburaviensis PA-39856. The individual factors, demethylolivomycins A, B and demethylchromomycins A2, A3 were separated and purified by preparative HLC. These antibiotics possess high activities against Gram-positive bacteria and P388 leukemia in mice.

MeSH terms

  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Chemical Phenomena
  • Chemistry
  • Magnetic Resonance Spectroscopy
  • Streptomyces / metabolism

Substances

  • Antibiotics, Antineoplastic