Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):e185-e192. doi: 10.1161/ATVBAHA.120.315737. Epub 2021 Jan 21.

Abstract

[Figure: see text].

Keywords: aging; artery; atherosclerosis; positron emission tomography; pravastatin; vascular; vascular calcification.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age Factors
  • Animals
  • Aorta / diagnostic imaging
  • Aorta / drug effects*
  • Aorta / metabolism
  • Aorta / pathology
  • Aortic Diseases / diagnostic imaging
  • Aortic Diseases / drug therapy*
  • Aortic Diseases / metabolism
  • Aortic Diseases / pathology
  • Atherosclerosis / diagnostic imaging
  • Atherosclerosis / drug therapy*
  • Atherosclerosis / metabolism
  • Atherosclerosis / pathology
  • Calcium / metabolism*
  • Disease Models, Animal
  • Female
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Hyperlipidemias / blood
  • Hyperlipidemias / drug therapy*
  • Lipids / blood
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout, ApoE
  • Plaque, Atherosclerotic
  • Pravastatin / pharmacology*
  • Rupture, Spontaneous
  • Time Factors
  • Vascular Calcification / diagnostic imaging
  • Vascular Calcification / drug therapy*
  • Vascular Calcification / metabolism
  • Vascular Calcification / pathology

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Lipids
  • Pravastatin
  • Calcium