Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19

Respir Res. 2021 Jan 20;22(1):24. doi: 10.1186/s12931-021-01623-0.

Authors

Georgios D Kitsios¹, William Bain^{2

3}, Nameer Al-Yousif⁴, Radha Duttagupta⁵, Asim A Ahmed⁵, Bryan J McVerry², Alison Morris²

Affiliations

¹ Division of Pulmonary, Allergy and Critical Care Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh Medical Center, UPMC Montefiore Hospital, NW 628, 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA. [email protected].
² Division of Pulmonary, Allergy and Critical Care Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh Medical Center, UPMC Montefiore Hospital, NW 628, 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA.
³ Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
⁴ Department of Medicine, University of Pittsburgh Medical Center Mercy, Pittsburgh, PA, USA.
⁵ Karius Inc, Redwood City, CA, USA.

No abstract available

Publication types

Letter

MeSH terms

Bacterial Load
COVID-19 / blood
COVID-19 / diagnosis*
COVID-19 / mortality
COVID-19 / virology
COVID-19 Nucleic Acid Testing*
Cell-Free Nucleic Acids / blood*
Cell-Free Nucleic Acids / genetics
Coinfection / blood
Coinfection / diagnosis*
Coinfection / microbiology
Coinfection / mortality
DNA, Bacterial / blood*
DNA, Bacterial / genetics
DNA, Viral / blood*
Female
Humans
Male
Metagenomics*
Middle Aged
Pneumonia, Bacterial / blood
Pneumonia, Bacterial / diagnosis*
Pneumonia, Bacterial / microbiology
Pneumonia, Bacterial / mortality
Predictive Value of Tests
Prognosis
Prospective Studies
SARS-CoV-2 / genetics*
Sequence Analysis, DNA
Viral Load

Substances

Cell-Free Nucleic Acids
DNA, Bacterial
DNA, Viral

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