The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support

Anja Irmisch; Ximena Bonilla; Stéphane Chevrier; Kjong-Van Lehmann; Franziska Singer; Nora C Toussaint; Cinzia Esposito; Julien Mena; Emanuela S Milani; Ruben Casanova; Daniel J Stekhoven; Rebekka Wegmann; Francis Jacob; Bettina Sobottka; Sandra Goetze; Jack Kuipers; Jacobo Sarabia Del Castillo; Michael Prummer; Mustafa A Tuncel; Ulrike Menzel; Andrea Jacobs; Stefanie Engler; Sujana Sivapatham; Anja L Frei; Gabriele Gut; Joanna Ficek; Nicola Miglino; Tumor Profiler Consortium; Rudolf Aebersold; Marina Bacac; Niko Beerenwinkel; Christian Beisel; Bernd Bodenmiller; Reinhard Dummer; Viola Heinzelmann-Schwarz; Viktor H Koelzer; Markus G Manz; Holger Moch; Lucas Pelkmans; Berend Snijder; Alexandre P A Theocharides; Markus Tolnay; Andreas Wicki; Bernd Wollscheid; Gunnar Rätsch; Mitchell P Levesque

doi:10.1016/j.ccell.2021.01.004

The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support

Cancer Cell. 2021 Mar 8;39(3):288-293. doi: 10.1016/j.ccell.2021.01.004. Epub 2021 Jan 21.

Authors

Anja Irmisch¹, Ximena Bonilla², Stéphane Chevrier³, Kjong-Van Lehmann², Franziska Singer⁴, Nora C Toussaint⁴, Cinzia Esposito⁵, Julien Mena⁶, Emanuela S Milani⁷, Ruben Casanova³, Daniel J Stekhoven⁴, Rebekka Wegmann⁶, Francis Jacob⁸, Bettina Sobottka⁹, Sandra Goetze⁷, Jack Kuipers¹⁰, Jacobo Sarabia Del Castillo⁵, Michael Prummer⁴, Mustafa A Tuncel¹⁰, Ulrike Menzel¹¹, Andrea Jacobs³, Stefanie Engler³, Sujana Sivapatham³, Anja L Frei⁹, Gabriele Gut⁵, Joanna Ficek², Nicola Miglino¹²; Tumor Profiler Consortium; Rudolf Aebersold⁶, Marina Bacac¹³, Niko Beerenwinkel¹⁰, Christian Beisel¹¹, Bernd Bodenmiller¹⁴, Reinhard Dummer¹, Viola Heinzelmann-Schwarz¹⁵, Viktor H Koelzer⁹, Markus G Manz¹², Holger Moch⁹, Lucas Pelkmans⁵, Berend Snijder¹⁶, Alexandre P A Theocharides¹², Markus Tolnay¹⁷, Andreas Wicki¹⁸, Bernd Wollscheid⁷, Gunnar Rätsch¹⁹, Mitchell P Levesque²⁰

Collaborators

Tumor Profiler Consortium:
Melike Ak, Faisal S Al-Quaddoomi, Jonas Albinus, Ilaria Alborelli, Sonali Andani, Per-Olof Attinger, Daniel Baumhoer, Beatrice Beck-Schimmer, Lara Bernasconi, Anne Bertolini, Natalia Chicherova, Maya D'Costa, Esther Danenberg, Natalie Davidson, Monica-Andreea Drăgan, Martin Erkens, Katja Eschbach, André Fedier, Pedro Ferreira, Bruno Frey, Linda Grob, Detlef Günther, Martina Haberecker, Pirmin Haeuptle, Sylvia Herter, Rene Holtackers, Tamara Huesser, Tim M Jaeger, Katharina Jahn, Alva R James, Philip M Jermann, André Kahles, Abdullah Kahraman, Werner Kuebler, Christian P Kunze, Christian Kurzeder, Sebastian Lugert, Gerd Maass, Philipp Markolin, Julian M Metzler, Simone Muenst, Riccardo Murri, Charlotte K Y Ng, Stefan Nicolet, Marta Nowak, Patrick G A Pedrioli, Salvatore Piscuoglio, Mathilde Ritter, Christian Rommel, María L Rosano-González, Natascha Santacroce, Ramona Schlenker, Petra C Schwalie, Severin Schwan, Tobias Schär, Gabriela Senti, Vipin T Sreedharan, Stefan Stark, Tinu M Thomas, Vinko Tosevski, Marina Tusup, Audrey Van Drogen, Marcus Vetter, Tatjana Vlajnic, Sandra Weber, Walter P Weber, Michael Weller, Fabian Wendt, Norbert Wey, Mattheus H E Wildschut, Shuqing Yu, Johanna Ziegler, Marc Zimmermann, Martin Zoche, Gregor Zuend

Affiliations

¹ University Hospital Zurich, Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland.
² ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6, 8092 Zurich, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Hospital Zurich, Biomedical Informatics, Schmelzbergstrasse 26, 8006 Zurich, Switzerland.
³ University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
⁴ SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, NEXUS Personalized Health Technologies, John-von-Neumann-Weg 9, 8093 Zurich, Switzerland.
⁵ University of Zurich, Department of Molecular Life Sciences, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
⁶ ETH Zurich, Department of Biology, Institute of Molecular Systems Biology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.
⁷ ETH Zurich, Department of Health Sciences and Technology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.
⁸ University Hospital Basel and University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland.
⁹ University Hospital Zurich, Department of Pathology and Molecular Pathology, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.
¹⁰ SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.
¹¹ ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, Switzerland.
¹² University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091 Zurich, Switzerland.
¹³ Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Wagistrasse 10, 8952 Schlieren, Switzerland.
¹⁴ University of Zurich, Department of Quantitative Biomedicine, Winterthurerstrasse 190, 8057 Zurich, Switzerland; ETH Zurich, Institute of Molecular Health Sciences, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.
¹⁵ University Hospital Basel and University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland; University Hospital Basel, Gynecological Cancer Center, Spitalstrasse 21, 4031 Basel, Switzerland.
¹⁶ SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; ETH Zurich, Department of Biology, Institute of Molecular Systems Biology, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.
¹⁷ University Hospital Basel, Institute of Medical Genetics and Pathology, Schönbeinstrasse 40, 4031 Basel, Switzerland.
¹⁸ University Hospital Zurich, Department of Medical Oncology and Hematology, Rämistrasse 100, 8091 Zurich, Switzerland; University of Zurich, Faculty of Medicine, Zurich, Switzerland.
¹⁹ ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6, 8092 Zurich, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Hospital Zurich, Biomedical Informatics, Schmelzbergstrasse 26, 8006 Zurich, Switzerland; ETH Zurich, Department of Biology, Wolfgang-Pauli-Strasse 27, 8093 Zurich, Switzerland. Electronic address: [email protected].
²⁰ University Hospital Zurich, Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland. Electronic address: [email protected].

PMID: 33482122
DOI: 10.1016/j.ccell.2021.01.004

Abstract

The application and integration of molecular profiling technologies create novel opportunities for personalized medicine. Here, we introduce the Tumor Profiler Study, an observational trial combining a prospective diagnostic approach to assess the relevance of in-depth tumor profiling to support clinical decision-making with an exploratory approach to improve the biological understanding of the disease.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Clinical Decision-Making / methods
Computational Biology / methods
Decision Support Systems, Clinical
Humans
Neoplasms / genetics*
Neoplasms / metabolism*
Precision Medicine / methods
Prospective Studies