Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

J Pediatr. 2021 May:232:287-289.e4. doi: 10.1016/j.jpeds.2021.01.027. Epub 2021 Jan 21.

Abstract

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019-compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.

Keywords: COVID-19; PCR; SARS-CoV-2; antigen test.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adolescent
  • Antigens, Viral / analysis*
  • COVID-19 / diagnosis*
  • COVID-19 / virology
  • Child
  • Child, Preschool
  • DNA, Viral / analysis*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Nasopharynx / virology*
  • Pandemics
  • Reproducibility of Results
  • Reverse Transcriptase Polymerase Chain Reaction / methods*
  • SARS-CoV-2 / genetics*
  • SARS-CoV-2 / immunology

Substances

  • Antigens, Viral
  • DNA, Viral