Polyclonal Dissemination of NDM-1- and NDM-9-Producing Escherichia coli and Klebsiella pneumoniae in French Polynesia

Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02437-20. doi: 10.1128/AAC.02437-20. Print 2021 Mar 18.

Abstract

The whole-genome sequencing analysis revealed a polyclonal dissemination of NDM-1 and NDM-9 variants in Escherichia coli (n = 20) and Klebsiella pneumoniae (n = 2) in Tahiti since 2015 via interspecies transfer of three different blaNDM-carrying plasmids (IncR, IncHI2, and IncF) and patient-to-patient cross-transmission. It highlights the potential risk of importation of NDM producers in France, where French Polynesia is not considered stricto sensu a foreign country from which repatriated patients have to be screened.

Keywords: Escherichia coli; NDM-1; NDM-9; Tahiti; epidemiology; whole-genome sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Escherichia coli / genetics
  • France
  • Humans
  • Klebsiella Infections* / drug therapy
  • Klebsiella pneumoniae* / genetics
  • Plasmids / genetics
  • Polynesia
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases
  • beta-lactamase NDM-1