To Induce Immune Reconstitution Inflammatory Syndrome or Suppress It: The Spectrum of Mycobacterium genavense in the Antiretroviral Era

Maura Manion; Niamh Lynn; Luxin Pei; Dima A Hammoud; Elizabeth Laidlaw; Gregg Roby; Dorinda Metzger; Yolanda Mejia; Andrea Lisco; Adrian Zelazny; Steve Holland; Marie-Louise Vachon; Matthew Scherer; Colm Bergin; Irini Sereti

doi:10.1093/cid/ciaa753

To Induce Immune Reconstitution Inflammatory Syndrome or Suppress It: The Spectrum of Mycobacterium genavense in the Antiretroviral Era

Clin Infect Dis. 2021 Jan 27;72(2):315-318. doi: 10.1093/cid/ciaa753.

Authors

Affiliations

¹ National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
² St James's Hospital, Dublin, Ireland.
³ Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
⁴ Leidos, Frederick, Maryland, USA.
⁵ Centre hospitalier universitaire de Quebec-Université Laval, Quebec City, Quebec, Canada.
⁶ Division of Infectious Diseases, Department of Internal Medicine, Columbia University Irving Medical Center, New York, New York, USA.

Abstract

Mycobacterium genavense is a challenging opportunistic pathogen to diagnose and manage in patients with human immunodeficiency virus (HIV). Persistent immunosuppression or protracted immune reconstitution inflammatory syndrome can lead to complicated clinical courses. We describe 3 cases of M. genavense in patients with HIV representing the spectrum between disease burden and strength of immune response.

Keywords: Mycobacterium genavense; HIV; IRIS.

Publication types

Research Support, N.I.H., Intramural

MeSH terms

HIV Infections* / drug therapy
Humans
Immune Reconstitution Inflammatory Syndrome*
Mycobacterium*
Nontuberculous Mycobacteria

Supplementary concepts

Mycobacterium genavense