Multiphasic Prehabilitation Across the Cancer Continuum: A Narrative Review and Conceptual Framework

Daniel Santa Mina; Stefanus J van Rooijen; Enrico M Minnella; Shabbir M H Alibhai; Priya Brahmbhatt; Susanne O Dalton; Chelsia Gillis; Michael P W Grocott; Doris Howell; Ian M Randall; Catherine M Sabiston; Julie K Silver; Gerrit Slooter; Malcolm West; Sandy Jack; Franco Carli

doi:10.3389/fonc.2020.598425

Multiphasic Prehabilitation Across the Cancer Continuum: A Narrative Review and Conceptual Framework

Front Oncol. 2021 Jan 11:10:598425. doi: 10.3389/fonc.2020.598425. eCollection 2020.

Authors

Daniel Santa Mina^{1

2

3}, Stefanus J van Rooijen⁴, Enrico M Minnella^{5

6}, Shabbir M H Alibhai³, Priya Brahmbhatt^{1

2}, Susanne O Dalton^{7

8}, Chelsia Gillis⁹, Michael P W Grocott^{10

11}, Doris Howell¹², Ian M Randall^{2

3}, Catherine M Sabiston¹, Julie K Silver¹³, Gerrit Slooter⁴, Malcolm West^{10

14}, Sandy Jack^{10

14}, Franco Carli⁵

Affiliations

¹ Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
² Department of Anesthesia and Pain Management, University Health Network, Toronto, ON, Canada.
³ Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
⁴ Department of Surgical Oncology, Máxima Medical Center, Veldhoven, Netherlands.
⁵ Department of Anesthesia, McGill University Health Center, Montreal, QC, Canada.
⁶ Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milano, Italy.
⁷ Danish Cancer Society Research Center, Copenhagen, Denmark.
⁸ Department of Clinical Oncology & Palliative Care, Zealand University Hospital, Næstved, Denmark.
⁹ Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
¹⁰ Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
¹¹ Acute Perioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Trust, University of Southampton, Southampton, United Kingdom.
¹² Faculty of Nursing, University of Toronto, Toronto, ON, Canada.
¹³ Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, United States.
¹⁴ NIHR Biomedical Research Centre, University Hospital Southampton NHS Trusts, Southampton, United Kingdom.

Abstract

The field of cancer survivorship has significantly advanced person-centered care throughout the cancer continuum. Within cancer survivorship, the last decade has seen remarkable growth in the investigation of prehabilitation comprising pre-treatment interventions to prevent or attenuate the burden of oncologic therapies. While the majority of evidence remains in the surgical setting, prehabilitation is being adapted to target modifiable risk factors that predict poor treatment outcomes in patients receiving other systemic and localized anti-tumor treatments. Here, we propose a multiphasic approach for prehabilitation across the cancer continuum, as a conceptual framework, to encompass the variability in cancer treatment experiences while adopting the most inclusive definition of the cancer survivor.

Keywords: cancer; conceptual framework; continuum of care; enhanced recovery after surgery; oncology; prehabilitation; rehabilitation; survivorship.

Publication types

Review