Systematic review of the potential of MicroRNAs in the management of patients with follicular lymphoma

Javier Arzuaga-Mendez; Maria Lopez-Santillan; Juan Carlos Garcia-Ruiz; Elixabet Lopez-Lopez; Idoia Martin-Guerrero

doi:10.1016/j.critrevonc.2021.103247

Systematic review of the potential of MicroRNAs in the management of patients with follicular lymphoma

Crit Rev Oncol Hematol. 2021 Mar:159:103247. doi: 10.1016/j.critrevonc.2021.103247. Epub 2021 Jan 27.

Authors

Javier Arzuaga-Mendez¹, Maria Lopez-Santillan², Juan Carlos Garcia-Ruiz³, Elixabet Lopez-Lopez⁴, Idoia Martin-Guerrero⁵

Affiliations

¹ Hematology Service. Hematologic Cancer Group, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Osakidetza, Plaza Cruces s/n, Barakaldo, Spain; Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursing and Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain.
² Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursing and Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain; Medical Oncology Service, Basurto University Hospital, Avenida de Montevideo, 18, 48013, Bilbao, Spain.
³ Hematology Service. Hematologic Cancer Group, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Osakidetza, Plaza Cruces s/n, Barakaldo, Spain.
⁴ Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursing and Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain; Pediatric Oncology Group, Biocruces Bizkaia Health Research Institute, Plaza Cruces s/n, 48903 Barakaldo, Spain. Electronic address: [email protected].
⁵ Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursing and Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain; Pediatric Oncology Group, Biocruces Bizkaia Health Research Institute, Plaza Cruces s/n, 48903 Barakaldo, Spain.

PMID: 33515703
DOI: 10.1016/j.critrevonc.2021.103247

Abstract

Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma and usually presents as an indolent disease. However, some patients present poor outcomes, and FL can transform into more aggressive lymphomas, such as Diffuse Large B cell lymphoma (DLBCL). MicroRNAs (miRNA) are small RNA molecules that participate in posttranscriptional regulation of gene expression, that are emerging biomarkers in cancer. In this systematic review, we included studies evaluating miRNA expression in tumor tissue as diagnosis, transformation or prognosis biomarkers in FL. We identified several miRNAs, which could be diagnostic biomarkers in FL: miR-155-5p and miR-9-3p as miRNAs of potential utility for diagnosis of FL, and miR-150 and miR-17-92 cluster for differential diagnosis between FL and DLBCL. Prognosis and transformation prediction have not been studied in enough depth to draw solid conclusions. Further research is needed to exploit the potential of this field.

Keywords: Diagnosis; Follicular lymphoma; Prognosis; Transformation; microRNA.

Publication types

Review
Systematic Review

MeSH terms

Gene Expression Regulation, Neoplastic
Humans
Lymphoma, Follicular* / diagnosis
Lymphoma, Follicular* / genetics
Lymphoma, Follicular* / therapy
Lymphoma, Large B-Cell, Diffuse* / diagnosis
Lymphoma, Large B-Cell, Diffuse* / genetics
Lymphoma, Large B-Cell, Diffuse* / therapy
MicroRNAs* / genetics
Prognosis

Substances

MicroRNAs