Clinical Significance of Past History of Breast Cancer Screening for the Prognosis of Triple Negative Breast Cancer

Anticancer Res. 2021 Feb;41(2):1077-1082. doi: 10.21873/anticanres.14865.

Abstract

Background/aim: This study examined the prognostic impact of the past history of breast cancer screening within the last 2 years (PH-BCS), for patients with triple negative breast cancer (TNBC), a subtype that carries extremely poor prognosis.

Patients and methods: Eighty-six consecutive cases with TNBC, who underwent surgery at our faculty from 2009 to 2015, were divided into two groups according to PH-BCS. Prognostic analyses for disease-free survival and overall survival between the two groups were performed.

Results: The positive PH-BCS group (n=44) had a significantly better prognoses than the negative PH-BCS group (n=42) (p<0.001). No recurrent cases were observed in the positive PH-BCS group. In the negative PH-BCS group, tumor and node status and chemotherapy were indicated as significant prognostic factors, and further step-wise multivariate analysis revealed only node status as a significant prognostic factor.

Conclusion: Breast cancer screening at least every 2 years may improve the prognosis of TNBC.

Keywords: Triple negative breast cancer; breast cancer screening; prognosis.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Drug Therapy
  • Early Detection of Cancer / methods*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Middle Aged
  • Prognosis
  • Survival Analysis
  • Triple Negative Breast Neoplasms / diagnosis*
  • Triple Negative Breast Neoplasms / drug therapy
  • Triple Negative Breast Neoplasms / mortality*
  • Triple Negative Breast Neoplasms / pathology