Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin

Marco De Dominici; James DeGregori

doi:10.1158/2159-8290.CD-20-1644

Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin

Cancer Discov. 2021 Feb;11(2):227-229. doi: 10.1158/2159-8290.CD-20-1644.

Authors

Marco De Dominici¹, James DeGregori²

Affiliations

¹ Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
² Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado. [email protected].

PMID: 33531425
DOI: 10.1158/2159-8290.CD-20-1644

Abstract

In this issue of Cancer Discovery, Fowler and colleagues conduct a thorough characterization of the dynamics of mutant clones in phenotypically normal human skin. Their results extend previous studies by showing that human skin is composed in large part of clones harboring mutations frequently observed in human cancer, while at the same time they uncover a previously unappreciated biological heterogeneity among nearby clones and across different body sites.See related article by Fowler et al., p. 340.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Clone Cells
Humans
Mutation
Neoplasms* / epidemiology
Neoplasms* / genetics
Skin*

Abstract

Publication types

MeSH terms

Grants and funding