Challenges in understanding host genetics and severity of community-acquired pneumonia

Jordi Solé-Violán; Elisa Hernández-Brito; José Manuel Valencia-Gallardo; Estefanía Herrera-Ramos; Luis Borderías; M Luisa Briones; Olga Rajas; Jorge Freixinet; Leonardo Lorente; Antoni Payeras; José Ferreres; Nieves Carbonell; Nereida González-Quevedo; Jesús M González-Martín; Felipe Rodríguez de Castro; Carlos Rodríguez-Gallego

doi:10.1183/23120541.00745-2020

Challenges in understanding host genetics and severity of community-acquired pneumonia

ERJ Open Res. 2021 Jan 25;7(1):00745-2020. doi: 10.1183/23120541.00745-2020. eCollection 2021 Jan.

Authors

Jordi Solé-Violán^{1

2

3}, Elisa Hernández-Brito^{4

5

3}, José Manuel Valencia-Gallardo⁶, Estefanía Herrera-Ramos⁵, Luis Borderías⁷, M Luisa Briones⁸, Olga Rajas⁹, Jorge Freixinet¹⁰, Leonardo Lorente¹¹, Antoni Payeras¹², José Ferreres¹³, Nieves Carbonell¹³, Nereida González-Quevedo⁴, Jesús M González-Martín¹⁴, Felipe Rodríguez de Castro^{5

6}, Carlos Rodríguez-Gallego^{4

15}

Affiliations

¹ Intensive Care Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
² CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
³ These authors contributed equally to this work.
⁴ Dept of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
⁵ Dept of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
⁶ Dept of Respiratory Diseases, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
⁷ Dept of Respiratory Diseases, Hospital San Jorge, Huesca, Spain.
⁸ Dept of Respiratory Diseases, Hospital Clínico y Universitario de Valencia, Valencia, Spain.
⁹ Dept of Respiratory Diseases, Hospital Universitario de la Princesa, Madrid, Spain.
¹⁰ Dept of Thoracic Surgery, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
¹¹ Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Spain.
¹² Dept of Internal Medicine, Hospital Son Llatzer, Palma de Mallorca, Spain.
¹³ Intensive Care Unit, Hospital Clínico y Universitario de Valencia, Valencia, Spain.
¹⁴ Biostatistics Division, Research Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain.
¹⁵ University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.

Abstract

This study found no association of the top two associated FER variants with severity of community-acquired pneumonia. Precise characterisation of phenotypes may be required in order to unravel the genetic mechanisms predisposing to poor outcome in sepsis. https://bit.ly/3jc9SmR.