Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1446-1458. doi: 10.1161/ATVBAHA.120.315321. Epub 2021 Feb 4.

Leda Coelewij^{1

2}, Kirsty E Waddington^#^{1

2}, George A Robinson^#^{2

3}, Elvira Chocano¹, Thomas McDonnell², Filipa Farinha², Junjie Peng^{2

3}, Pierre Dönnes^{2

4}, Edward Smith², Sara Croca², Jyoti Bakshi², Maura Griffin⁵, Andrew Nicolaides^{5

6}, Anisur Rahman², Elizabeth C Jury², Ines Pineda-Torra¹

¹ Department of Medicine, Centre for Cardiometabolic and Vascular Science, University College London, United Kingdom (L.C., K.E.W., E.C., I.P.-T.).
² Centre for Rheumatology Research (L.C., K.E.W., G.A.R., E.C., T.M., F.F., J.P., P.D., E.S., S.C., J.B., A.R., E.C.J.), University College London, United Kingdom.
³ Department of Medicine, Centre for Adolescent Rheumatology Versus Arthritis (G.A.R., J.P.), University College London, United Kingdom.
⁴ Scicross AB, Skövde, Sweden (P.D.).
⁵ Vascular Screening and Diagnostic Centre, London, United Kingdom (M.G., A.N.).
⁶ St Georges London/Nicosia Medical School, University of Nicosia, Cyprus (A.N.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: atherosclerosis; lipoprotein; lupus erythematosus, systemic; machine learning; metabolomics.