[Congenital hepatic fibrosis: apropos of 12 cases]

An Esp Pediatr. 1988 Feb;28(2):111-4.
[Article in Spanish]

Abstract

Twelve patients with congenital hepatic fibrosis have been retrospectively studied and followed for 1 to 14 years. Clinical features, hepatic function tests and biopsy have been analyzed. Presence of portal hypertension and congenital malformation have been investigated. Clinical presentations varies from newborn to nine years of age without male or female predominance. Most frequent clinical form has been hypertensive type. Cholangitic type has worse prognosis. Familiar recurrence rate is 20%. Congenital malformations are associated in 92% most frequently infantile polycystic kidney disease. Hepatic biopsy has confirmed diagnosis in all patients.

Publication types

  • English Abstract

MeSH terms

  • Child
  • Child, Preschool
  • Cholangitis / etiology
  • Female
  • Humans
  • Hypertension / etiology
  • Infant
  • Infant, Newborn
  • Kidney Diseases / etiology
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / congenital*
  • Liver Cirrhosis / genetics
  • Liver Cirrhosis / pathology
  • Male
  • Retrospective Studies