A Malignant Case of Arrested Development: Cancer Cell Dormancy Mimics Embryonic Diapause

Yu-Hsuan Lin; Hao Zhu

doi:10.1016/j.ccell.2021.01.013

A Malignant Case of Arrested Development: Cancer Cell Dormancy Mimics Embryonic Diapause

Cancer Cell. 2021 Feb 8;39(2):142-144. doi: 10.1016/j.ccell.2021.01.013.

Authors

Yu-Hsuan Lin¹, Hao Zhu²

Affiliations

¹ Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected].

PMID: 33561394
DOI: 10.1016/j.ccell.2021.01.013

Abstract

Writing in Cancer Cell and Cell, two groups investigate the nature of dormant cancer cells that persist after chemotherapy. These cells adopt a state that resembles diapause, an evolutionarily conserved adaptation used by embryos to survive inhospitable conditions. Understanding cancer diapause could uncover therapeutic strategies that reduce cancer relapse.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adaptation, Physiological
Animals
Diapause*
Neoplasms*

Grants and funding

R01 CA251928/CA/NCI NIH HHS/United States