Nanotomography of lesional skin using electron microscopy reveals cytosolic release of nuclear DNA in psoriasis

Eric Lindberg; Yvonne Baumer; Erin S Stempinski; Justin A Rodante; Tiffany M Powell-Wiley; Amit K Dey; Saeko Nakajima; Martin P Playford; Christopher K E Bleck; Nehal N Mehta

doi:10.1016/j.jdcr.2020.12.024

Nanotomography of lesional skin using electron microscopy reveals cytosolic release of nuclear DNA in psoriasis

JAAD Case Rep. 2021 Jan 6:9:9-14. doi: 10.1016/j.jdcr.2020.12.024. eCollection 2021 Mar.

Authors

Affiliations

¹ Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
² Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
³ Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
⁴ Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

No abstract available

Keywords: DNA release; FIB-SEM; FIB-SEM, Focused Ion Beam Scanning Electron Microscopy; NHLBI, National Heart, Lung and Blood Institute; NIH, National Institutes of Health; SEM, scanning electron microscope; inflammation; keratinocytes; psoriasis.

Publication types

Case Reports