Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Thomas M Wilkie; Michael A Hale; Sarthak Reddy

doi:10.1016/j.ceca.2020.102340

Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Cell Calcium. 2021 Mar:94:102340. doi: 10.1016/j.ceca.2020.102340. Epub 2021 Jan 18.

Authors

Thomas M Wilkie¹, Michael A Hale², Sarthak Reddy³

Affiliations

¹ Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA; Cancer Discovery Team, Wilkie Laboratory, Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA. Electronic address: [email protected].
² Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA; Cancer Discovery Team, Wilkie Laboratory, Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA.
³ Cancer Discovery Team, Wilkie Laboratory, Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA.

PMID: 33601151
DOI: 10.1016/j.ceca.2020.102340

Abstract

The recent paper by Pfeil et al., "Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs", opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.

Keywords: Calcium signaling; Gi signaling; Gq signaling; RGS proteins.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Calcium Signaling
Calcium* / metabolism
GTP-Binding Protein alpha Subunits, Gq-G11* / metabolism
Phospholipase C beta / metabolism

Substances

Phospholipase C beta
GTP-Binding Protein alpha Subunits, Gq-G11
Calcium

Grants and funding

R01 CA192381/CA/NCI NIH HHS/United States