Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

Niels G A Willemen; Shabir Hassan; Melvin Gurian; Jinghang Li; Iris E Allijn; Su Ryon Shin; Jeroen Leijten

doi:10.1016/j.tibtech.2021.01.007

Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

Trends Biotechnol. 2021 Nov;39(11):1144-1159. doi: 10.1016/j.tibtech.2021.01.007. Epub 2021 Feb 16.

Authors

Niels G A Willemen¹, Shabir Hassan², Melvin Gurian³, Jinghang Li⁴, Iris E Allijn³, Su Ryon Shin⁵, Jeroen Leijten⁶

Affiliations

¹ Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA.
² Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA.
³ Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands.
⁴ Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA; School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
⁵ Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA. Electronic address: [email protected].
⁶ Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands. Electronic address: [email protected].

Abstract

Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.

Keywords: biomaterials; hypoxia; metabolism; oxygen generation; sustained release.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials
Cell Differentiation
Mammals
Oxygen* / metabolism
Regenerative Medicine
Tissue Engineering*

Substances

Biocompatible Materials
Oxygen

Grants and funding

R01 AR074234/AR/NIAMS NIH HHS/United States