Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability

L Barrios; M R Caballín; R Mirò; C Fuster; G Berrozpe; A Subías; X Batlle; J Egozcue

doi:10.1007/BF00291727

Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability

Hum Genet. 1988 Apr;78(4):320-4. doi: 10.1007/BF00291727.

Authors

L Barrios¹, M R Caballín, R Mirò, C Fuster, G Berrozpe, A Subías, X Batlle, J Egozcue

Affiliation

¹ Departament de Biologia Cel.lular i Fisiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.

PMID: 3360446
DOI: 10.1007/BF00291727

Abstract

We describe the presence of a high frequency of spontaneous chromosome aberrations in lymphocytes from six untreated patients with Hodgkin's disease. The characteristics of the chromosome abnormalities observed suggest the existence of a certain degree of chromosome instability in these cases, that could be a predisposing factor for the development of malignancies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Chromosome Aberrations*
Female
Hodgkin Disease / genetics*
Humans
Lymphocytes / ultrastructure*
Male
Middle Aged