The Complement Pathway Is Activated in People With Human Immunodeficiency Virus and Is Associated With Non-AIDS Comorbidities

Ivan Vujkovic-Cvijin; Ornella Sortino; Eveline Verheij; Ferdinand W Wit; Neeltje A Kootstra; Brian Sellers; Maarten Schim van der Loeff; Yasmine Belkaid; Peter Reiss; Irini Sereti

doi:10.1093/infdis/jiab096

The Complement Pathway Is Activated in People With Human Immunodeficiency Virus and Is Associated With Non-AIDS Comorbidities

J Infect Dis. 2021 Oct 28;224(8):1405-1409. doi: 10.1093/infdis/jiab096.

Authors

Affiliations

¹ Metaorganism Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
² Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA.
³ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
⁴ Amsterdam University Medical Centers, University of Amsterdam, Department of Global Health and Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, and Amsterdam Institute for Global Health and Development, Amsterdam,The Netherlands.
⁵ Amsterdam University Medical Centers, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands.
⁶ Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, Maryland, USA.
⁷ Public Health Service of Amsterdam, Department of Infectious Diseases, Amsterdam, The Netherlands.

Abstract

Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

Keywords: HIV; biomarker; comorbidities; complement; noncommunicable diseases.

Published by Oxford University Press for the Infectious Diseases Society of America 2021.

Publication types

Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Aging
Biomarkers / blood
Case-Control Studies
Comorbidity
Complement C5 / analysis*
HIV
HIV Infections / epidemiology*
HIV Seronegativity
Humans
Immunologic Factors

Substances

Biomarkers
Complement C5
Immunologic Factors