A time to build and a time to burn: glucose metabolism for every season

William B McKean; Ashish G Toshniwal; Jared Rutter

doi:10.1016/j.molcel.2021.02.003

A time to build and a time to burn: glucose metabolism for every season

Mol Cell. 2021 Feb 18;81(4):642-644. doi: 10.1016/j.molcel.2021.02.003.

Authors

William B McKean¹, Ashish G Toshniwal², Jared Rutter³

Affiliations

¹ Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA; Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
² Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA.
³ Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. Electronic address: [email protected].

PMID: 33606971
DOI: 10.1016/j.molcel.2021.02.003

Abstract

Luengo et al. (2020) demonstrate that pyruvate dehydrogenase (PDH) overactivation blunts NAD⁺ regeneration by overcharging the mitochondrial membrane potential and driving ATP synthesis beyond demand. Under these conditions, some cells prioritize aerobic glycolysis to meet the need for oxidized cofactors in biosynthetic metabolism.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adenosine Triphosphate
Glucose
Glycolysis
NAD* / metabolism
Pyruvate Dehydrogenase Complex* / metabolism
Seasons

Substances

Pyruvate Dehydrogenase Complex
NAD
Adenosine Triphosphate
Glucose

Grants and funding

HHMI/Howard Hughes Medical Institute/United States