"Iron"ing out hemophagocytosis through PIEZO1

Neil A Hanchard; Ambroise Wonkam

doi:10.1016/j.cell.2021.01.038

"Iron"ing out hemophagocytosis through PIEZO1

Cell. 2021 Feb 18;184(4):856-858. doi: 10.1016/j.cell.2021.01.038.

Authors

Neil A Hanchard¹, Ambroise Wonkam²

Affiliations

¹ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address: [email protected].
² Division of Human Genetics, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Abstract

In this issue of Cell, Ma et al. reveal a mechanistic role for PIEZO1 in iron homeostasis through molecular genetic mouse studies. They also demonstrate implications for human iron overload and deficiency syndromes, susceptibility to malarial infection, and red blood cell turnover in persons of African ancestries.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Erythrocytes
Homeostasis
Humans
Ion Channels / genetics
Iron*
Malaria*
Mice

Substances

Ion Channels
PIEZO1 protein, human
Piezo1 protein, mouse
Iron

Grants and funding

U24 HL135600/HL/NHLBI NIH HHS/United States