Activation of CXCL16/CXCR6 axis aggravates cardiac ischemia/reperfusion injury by recruiting the IL-17a-producing CD1d⁺ T cells

Clin Transl Med. 2021 Feb;11(2):e301. doi: 10.1002/ctm2.301.

Authors

Shijun Wang^{1

2}, Leilei Ma¹, Ji'e Yang¹, Zhen Dong¹, Jian Wu^{1

2}, Xiancheng Lu³, Jiahong Wang⁴, Fangjie Dai¹, Guowei Tu¹, Lei Xu¹, Gang Zhao¹, Feng Zhang¹, Yunzeng Zou^{1

2}, Junbo Ge^{1

2}

Affiliations

¹ Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
² Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
³ Department of outpatient, Shanghai Yangpu Hospital of Traditional Chinese Medicine, Shanghai, China.
⁴ Department of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chemokine CXCL16 / metabolism*
Disease Models, Animal
Heart Injuries / etiology*
Heart Injuries / metabolism
Heart Injuries / physiopathology
Interleukin-17 / metabolism*
Mice
Receptors, CXCR6 / metabolism*
Reperfusion Injury / complications*
Reperfusion Injury / metabolism
Reperfusion Injury / physiopathology
T-Lymphocytes / metabolism*

Substances

Chemokine CXCL16
Interleukin-17
Receptors, CXCR6