Abstract
Laucysteinamide A (4) is a marine natural product isolated from the cyanobacterium Caldora penicillata and contains structural motifs found in promising cancer drug leads. The first total synthesis of 4 and its analogues was achieved, which also enabled a concise formal synthesis of somocystinamide A (3), a dimeric congener of 4 that previously showed extremely potent antiproliferative activities. This work provides further insights on structure-activity relationships in this class of natural products.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Biological Products / chemistry
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Biological Products / pharmacology
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Cell Line, Tumor
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Cyanobacteria / chemistry
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Disulfides / chemistry*
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Humans
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Molecular Structure
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Structure-Activity Relationship
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology
Substances
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Antineoplastic Agents
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Biological Products
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Disulfides
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Somocystinamide A
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Thiazoles
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laucysteinamide A