Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

Penghui Yang; Yingze Zhao; Jie Li; Chuanyu Liu; Linnan Zhu; Jie Zhang; Yeya Yu; Wen-Jing Wang; Guanglin Lei; Jin Yan; Fang Sun; Chengrong Bian; Fanping Meng; Zhe Xu; Changqing Bai; Beiwei Ye; Yuanyuan Guo; Liumei Shu; Xiaoju Yuan; Ning Zhang; Yuhai Bi; Yi Shi; Guizhen Wu; Shaogeng Zhang; George F Gao; Longqi Liu; William J Liu; Hai-Xi Sun

doi:10.1038/s41423-021-00652-5

Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

Cell Mol Immunol. 2021 Apr;18(4):1064-1066. doi: 10.1038/s41423-021-00652-5. Epub 2021 Feb 26.

Authors

Penghui Yang^#¹, Yingze Zhao^#², Jie Li^#^{3

4}, Chuanyu Liu^#^{3

5}, Linnan Zhu^#^{3

5}, Jie Zhang², Yeya Yu^{3

6}, Wen-Jing Wang³, Guanglin Lei¹, Jin Yan¹, Fang Sun¹, Chengrong Bian¹, Fanping Meng¹, Zhe Xu¹, Changqing Bai¹, Beiwei Ye², Yuanyuan Guo^{2

7}, Liumei Shu², Xiaoju Yuan², Ning Zhang⁸, Yuhai Bi⁸, Yi Shi⁸, Guizhen Wu², Shaogeng Zhang⁹, George F Gao^{10

11}, Longqi Liu^{12

13}, William J Liu¹⁴, Hai-Xi Sun¹⁵

Affiliations

¹ Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
² NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
³ BGI-Shenzhen, Shenzhen, China.
⁴ BGI Education Center, University of Chinese Academic of Sciences, Shenzhen, China.
⁵ Shenzhen Bay Laboratory, Shenzhen, China.
⁶ BGI College, Zhengzhou University, Zhengzhou, China.
⁷ School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
⁸ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
⁹ Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China. [email protected].
¹⁰ NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. [email protected].
¹¹ School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China. [email protected].
¹² BGI-Shenzhen, Shenzhen, China. [email protected].
¹³ Shenzhen Bay Laboratory, Shenzhen, China. [email protected].
¹⁴ NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. [email protected].
¹⁵ BGI-Shenzhen, Shenzhen, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

COVID-19 / blood
COVID-19 / genetics
COVID-19 / immunology*
COVID-19 / metabolism*
Cell-Free Nucleic Acids / blood*
Cytokine Release Syndrome / blood
Cytokine Release Syndrome / immunology*
Down-Regulation
Humans
Interleukin-6 / metabolism*
MicroRNAs / blood*
MicroRNAs / genetics
MicroRNAs / metabolism
RNA / blood
Receptors, Interleukin-6 / genetics
Receptors, Interleukin-6 / metabolism*
SARS-CoV-2

Substances

Cell-Free Nucleic Acids
IL6 protein, human
IL6R protein, human
Interleukin-6
MIRN451 microRNA, human
MicroRNAs
Receptors, Interleukin-6
RNA