Multiple parameter analyses of human ovarian cancer: morphology, immunohistochemistry, steroid hormone receptors and aromatase

Anticancer Res. 1988 Mar-Apr;8(2):281-6.

Abstract

All human ovarian tumors (n = 32) analysed were positive for cytokeratin except for a single case. OV-TL 3 stained 96% (26/27) and 1 out of 4 controls, while OC-125 stained 86% (24/27) and 3 out of 4 non-ovarian carcinomas. Androgen receptors predominated (AR-96%) compared to estrogen (ER-32%) or progestin (PgR-50%) receptors in the ovarian carcinomas. Aromatase activity was detected in 6 ovarian carcinomas and in 3 non-ovarian carcinomas. No definite relationship was observed between the parameters measured. Ovarian carcinomas stained brightly with OV-TL 3 and OC-125 had high AR levels, while focal or absent reaction was related to low AR levels. A role for androgens in ovarian cancer is suggested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aromatase / analysis*
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Ovarian Neoplasms / analysis*
  • Ovarian Neoplasms / pathology
  • Receptors, Androgen / analysis
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis
  • Receptors, Steroid / analysis*

Substances

  • Receptors, Androgen
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Receptors, Steroid
  • Aromatase