The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A

Blood Adv. 2021 Mar 9;5(5):1305-1309. doi: 10.1182/bloodadvances.2020003259.

Abstract

  1. The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens.

  2. SARS-CoV-2 RBD binds the blood group A expressed on respiratory epithelial cells, directly linking blood group A and SARS-CoV-2.

MeSH terms

  • ABO Blood-Group System / genetics*
  • Alveolar Epithelial Cells / metabolism*
  • Amino Acid Sequence
  • COVID-19
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Consensus Sequence
  • Erythrocyte Membrane / metabolism
  • Galectin 4 / chemistry
  • Galectins / chemistry
  • Genetic Predisposition to Disease
  • Humans
  • Oligosaccharides / genetics
  • Oligosaccharides / metabolism*
  • Oligosaccharides, Branched-Chain
  • Organ Specificity
  • Protein Binding
  • Protein Domains
  • SARS-CoV-2
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / metabolism*
  • Substrate Specificity

Substances

  • ABO Blood-Group System
  • Galectin 4
  • Galectins
  • LGALS9 protein, human
  • Oligosaccharides
  • Oligosaccharides, Branched-Chain
  • Spike Glycoprotein, Coronavirus
  • blood group A trisaccharide
  • spike protein, SARS-CoV-2