How to make a better T cell: in vivo CRISPR screens have some answers

Matteo Villa; Michal A Stanczak; Erika L Pearce

doi:10.1016/j.cell.2021.02.003

How to make a better T cell: in vivo CRISPR screens have some answers

Cell. 2021 Mar 4;184(5):1135-1136. doi: 10.1016/j.cell.2021.02.003.

Authors

Matteo Villa¹, Michal A Stanczak¹, Erika L Pearce²

Affiliations

¹ Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
² Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA. Electronic address: [email protected].

PMID: 33667366
DOI: 10.1016/j.cell.2021.02.003

Abstract

Understanding what regulates CD8⁺ T cell responses is key to effectively harnessing these cells in human disease. In this issue of Cell, Huang et al. and Chen et al. use in vivo CRISPR screens to discover novel regulators of CD8⁺ T cell immunity to engineer a more efficacious response against cancer and infections.

Publication types

Comment

MeSH terms

Clustered Regularly Interspaced Short Palindromic Repeats*
Humans
Neoplasms* / genetics
T-Lymphocytes