Struggle for survival: new insights into NELF condensation for adaptive transcriptional reprogramming

Weifan Xu; Mingrui Ding; Pilong Li

doi:10.1016/j.molcel.2021.02.008

Struggle for survival: new insights into NELF condensation for adaptive transcriptional reprogramming

Mol Cell. 2021 Mar 4;81(5):896-898. doi: 10.1016/j.molcel.2021.02.008.

Authors

Weifan Xu¹, Mingrui Ding¹, Pilong Li²

Affiliations

¹ Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
² Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China. Electronic address: [email protected].

PMID: 33667379
DOI: 10.1016/j.molcel.2021.02.008

Abstract

In this issue of Molecular Cell, Rawat et al. (2021) characterize novel stress-induced condensates of the negative elongation factor (NELF) as the nuclear counterparts of cytosolic stress granules. This provides a new perspective on transcription repression orchestrated by phase separation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Nucleus* / metabolism
Down-Regulation
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Transcription Factors
negative elongation factor