Endothelial-Specific Deletion of CD146 Protects Against Experimental Glomerulonephritis in Mice

Hypertension. 2021 Apr;77(4):1260-1272. doi: 10.1161/HYPERTENSIONAHA.119.14176. Epub 2021 Mar 10.

Authors

Ahmed Abed^#^{1

2}, Aurélie S Leroyer^#³, Panagiotis Kavvadas^#¹, Florence Authier¹, Richard Bachelier³, Alexandrine Foucault-Bertaud³, Nathalie Bardin³, Clemens D Cohen⁴, Maja T Lindenmeyer⁵, Magali Genest¹, Ahmad Joshkon³, Noémie Jourde-Chiche^{3

6}, Stéphane Burtey^{3

6}, Marcel Blot-Chabaud^#³, Françoise Dignat-George^#³, Christos E Chadjichristos^#^{1

2}

Affiliations

¹ From the INSERM UMR-S1155, Tenon Hospital, Paris, France (A.A., P.K., F.A., M.G., C.E.C.).
² Sorbonne Université, Paris, France (A.A., C.E.C.).
³ Aix-Marseille University, INSERM 1263, INRAE 1260, C2VN, France (A.S.L., R.B., A.F.-B., N.B., A.J., N.J.-C., S.B., M.B.-C., F.D.-G.).
⁴ Nephrological Center, Medical Clinic and Policlinic IV, University of Munich, Germany (C.D.C.).
⁵ Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany (M.T.L.).
⁶ Department of Nephrology, Aix-Marseille University, AP-HM Hôpital de la Conception, Marseille, France (N.J.-C., S.B.).

^# Contributed equally.

PMID: 33689459
DOI: 10.1161/HYPERTENSIONAHA.119.14176

Abstract

[Figure: see text].

Keywords: fibrosis; inflammation; mice; monocyte; proteinuria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD146 Antigen* / genetics
CD146 Antigen* / metabolism
Disease Models, Animal
Drug Discovery
Endothelial Cells / metabolism
Fibrosis / metabolism
Fibrosis / prevention & control
Gene Knockout Techniques / methods
Glomerulonephritis* / immunology
Glomerulonephritis* / metabolism
Glomerulonephritis* / therapy
Inflammation / metabolism
Inflammation / prevention & control
Intercellular Junctions / immunology
Kidney Glomerulus / immunology
Mice
Up-Regulation

Substances

CD146 Antigen