Surgical Management of Wilms Tumor (Nephroblastoma) and Renal Cell Carcinoma in Children and Young Adults

Natalie M Lopyan; Peter F Ehrlich

doi:10.1016/j.soc.2020.11.002

Surgical Management of Wilms Tumor (Nephroblastoma) and Renal Cell Carcinoma in Children and Young Adults

Surg Oncol Clin N Am. 2021 Apr;30(2):305-323. doi: 10.1016/j.soc.2020.11.002. Epub 2021 Jan 29.

Authors

Natalie M Lopyan¹, Peter F Ehrlich²

Affiliations

¹ C.S. Mott Children's Hospital Section of Pediatric Surgery, 1540 East Hospital Drive, Ann Arbor, MI 48109, USA.
² University of Michigan, C.S. Mott Children's Hospital Section of Pediatric Surgery, 1540 East Hospital Drive, SPC 4811, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

PMID: 33706902
DOI: 10.1016/j.soc.2020.11.002

Abstract

This article reviews the epidemiology, pathophysiology, clinical presentation, and multimodality management of Wilms tumors and renal cell carcinoma in pediatric and young adults. Key renal Société Internationale d'Oncologie Pédiatrique and Children Oncology Group studies are presented. The article reviews the common staging systems and risk-adapted treatment strategies with particular attention to the surgical management.

Keywords: Pediatric Wilms tumor; Pediatric renal cell carcinoma; Treatment and surgical management.

Publication types

Review

MeSH terms

Carcinoma, Renal Cell* / surgery
Child
Humans
Kidney Neoplasms* / surgery
Wilms Tumor* / surgery
Young Adult