Is Carbapenem-resistant Klebsiella pneumoniae Infection in Pediatric Bone Marrow Transplantation Recipients Inevitably Fatal?

J Pediatr Hematol Oncol. 2022 Mar 1;44(2):e456-e459. doi: 10.1097/MPH.0000000000002142.

Abstract

Carbapenem resistance, most notably in Klebsiella pneumonia (KPC), results in infections associated with significant morbidity and mortality. Here we report 2 cases of adolescent patients with KPC infection after high-risk bone marrow transplantation, who eventually succumbed from other causes and review the epidemiology and treatment options for KPC infections in this vulnerable population.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / therapeutic use
  • Bone Marrow Transplantation / adverse effects
  • Carbapenem-Resistant Enterobacteriaceae*
  • Carbapenems / therapeutic use
  • Child
  • Humans
  • Klebsiella Infections* / drug therapy
  • Klebsiella Infections* / etiology
  • Klebsiella pneumoniae
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Carbapenems