In this communication, a concise and efficient synthetic route for the synthesis of (-)-Cephalosporolide D in enantioselective way has been described. In this synthesis, Mitsunobu esterification and Ring Closing Metathesis (RCM) for macrocyclic ring formation have been applied as key steps.
Keywords: (–)-Cephalosporolide D; Barbier allylation; Mitsunobu esterification; Ring Closing Metathesis (RCM).