Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile: A Phenome-Wide Association Study

Affiliations

• ¹ Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-University LMU, Munich, Germany (M.K.G., R.M., M.D.).
• ² Centre of Global Health, Usher Institute, University of Edinburgh, United Kingdom (X.L., E.T.).
• ³ School of Public Health and the Second Affiliated Hospital, Zhejiang University, Hangzhou, China (X.L.).
• ⁴ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom (D.G.).
• ⁵ Division of Cardiovascular Medicine, Department of Medicine (M.G.L.).
• ⁶ Charles Bronfman Institute for Personalized Medicine (H.M.T.V., G.N.N.).
• ⁷ Department of Surgery (R.J., S.M.D.).
• ⁸ Department of Genetics (M.R., S.S.V.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
• ⁹ Hasso Plattner Institute for Digital Health at Mount Sinai (G.N.N.).
• ¹⁰ Department of Medicine (G.N.N.), Icahn School of Medicine at Mount Sinai, New York.
• ¹¹ Department of Surgery, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania (S.M.D.).
• ¹² Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom (E.T.).
• ¹³ Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.).
• ¹⁴ German Centre for Neurodegenerative Diseases, Munich, Germany (M.D.).