Impaired Peyer's patch development in BOB.1/OBF.1-deficient mice

Annika C Betzler; Katja Fiedler; Enikö Kokai; Thomas Wirth; Thomas K Hoffmann; Cornelia Brunner

doi:10.1002/eji.202048578

Impaired Peyer's patch development in BOB.1/OBF.1-deficient mice

Eur J Immunol. 2021 Jul;51(7):1860-1863. doi: 10.1002/eji.202048578. Epub 2021 Mar 26.

Authors

Annika C Betzler¹, Katja Fiedler^{1

2}, Enikö Kokai², Thomas Wirth², Thomas K Hoffmann¹, Cornelia Brunner¹

Affiliations

¹ Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.
² Institute of Physiological Chemistry, Ulm University, Ulm, Germany.

PMID: 33733501
DOI: 10.1002/eji.202048578

Abstract

BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13-CXCR5 signaling of LT_inducer and LT_organizer cells during embryonic Peyer's patch organogenesis as well as of B cells and follicular dendritic cells during lymphocyte homing at postnatal stages of secondary lymphoid organ development.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
B-Lymphocytes
Chemokine CXCL13 / metabolism
Dendritic Cells, Follicular / metabolism
Mice
Organogenesis / physiology
Peyer's Patches / metabolism*
Receptors, CXCR5 / metabolism
Trans-Activators / deficiency*
Trans-Activators / metabolism*

Substances

Chemokine CXCL13
Pou2af1 protein, mouse
Receptors, CXCR5
Trans-Activators