Basics of Coronary Thermodilution

Alessandro Candreva; Emanuele Gallinoro; Marcel van 't Veer; Jeroen Sonck; Carlos Collet; Giuseppe Di Gioia; Monika Kodeboina; Takuya Mizukami; Sakura Nagumo; Danielle Keulards; Stephane Fournier; Nico H J Pijls; Bernard De Bruyne

doi:10.1016/j.jcin.2020.12.037

Basics of Coronary Thermodilution

JACC Cardiovasc Interv. 2021 Mar 22;14(6):595-605. doi: 10.1016/j.jcin.2020.12.037.

Affiliations

¹ Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
² Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy.
³ Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
⁴ Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
⁵ Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Showa University Fujigaoka Hospital, Kanagawa, Japan.
⁶ Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
⁷ Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: [email protected].

PMID: 33736767
DOI: 10.1016/j.jcin.2020.12.037

Abstract

Coronary microvascular dysfunction is a highly prevalent condition in both obstructive and nonobstructive coronary artery disease. Intracoronary thermodilution is a promising technique to investigate coronary microvascular (dys)function in vivo and to assess its most important metric: microvascular resistance. Here, the authors provide a practical review of bolus and continuous thermodilution for the measurement of coronary flow and microvascular resistance. The authors describe the basic principles of indicator-dilution theory and of coronary thermodilution and detail the practicalities of their application in the catheterization laboratory. Finally, the authors discuss contemporary clinical applications of coronary thermodilution-based microvascular assessment in humans and future perspectives.

Keywords: bolus coronary thermodilution; continuous coronary thermodilution; coronary microvascular dysfunction; indicator-dilution theory.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Coronary Circulation*
Coronary Vessels / diagnostic imaging
Humans
Microcirculation
Thermodilution*
Treatment Outcome
Vascular Resistance