Extravascular leakage of induction doses of rocuronium: four cases in which both depth of neuromuscular block and plasma concentration of rocuronium were assessed

Shunichi Takagi; Miho Kijima; Hajime Iwasaki; Akira Doshu-Kajiura; Osamu Kitajima; Takahiro Suzuki

doi:10.1007/s10877-021-00692-2

Extravascular leakage of induction doses of rocuronium: four cases in which both depth of neuromuscular block and plasma concentration of rocuronium were assessed

J Clin Monit Comput. 2022 Apr;36(2):587-592. doi: 10.1007/s10877-021-00692-2. Epub 2021 Mar 21.

Authors

Shunichi Takagi^#¹, Miho Kijima^#¹, Hajime Iwasaki¹, Akira Doshu-Kajiura¹, Osamu Kitajima¹, Takahiro Suzuki²

Affiliations

¹ Department of Anesthesiology, Nihon University School of Medicine, 30-1, Oyaguchi Kamimachi, Itabashi-Ku, Tokyo, 173-8610, Japan.
² Department of Anesthesiology, Nihon University School of Medicine, 30-1, Oyaguchi Kamimachi, Itabashi-Ku, Tokyo, 173-8610, Japan. [email protected].

^# Contributed equally.

PMID: 33745069
DOI: 10.1007/s10877-021-00692-2

Abstract

The duration of action of extravasated rocuronium varies depending on the patient's comorbidities. In patients who receive high doses of non-depolarizing neuromuscular blocking agents subcutaneously, anesthesiologists should be aware of unexpected prolongation of the progress and recovery of neuromuscular block. In such cases, the depth and recovery of neuromuscular block should be objectively monitored to avoid residual neuromuscular block and recurarization.

Keywords: Elimination; Extravascular leak; Rocuronium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Androstanols
Humans
Neuromuscular Blockade*
Neuromuscular Nondepolarizing Agents* / pharmacology
Rocuronium
Sugammadex

Substances

Androstanols
Neuromuscular Nondepolarizing Agents
Sugammadex
Rocuronium