Combined use of emapalumab and ruxolitinib in a patient with refractory hemophagocytic lymphohistiocytosis was safe and effective

Michael P Triebwasser; David M Barrett; Hamid Bassiri; Nancy Bunin; Caitlin Elgarten; Jason Freedman; Abdallah S Geera; Dimitri Monos; Michele P Lambert; Timothy Olson; Alix E Seif; Michele Paessler; Whitney Petrosa; Anne F Reilly; Neil Romberg; Kathleen E Sullivan; Ghazal Z Quinn; Edward Behrens; David T Teachey

doi:10.1002/pbc.29026

Combined use of emapalumab and ruxolitinib in a patient with refractory hemophagocytic lymphohistiocytosis was safe and effective

Pediatr Blood Cancer. 2021 Jul;68(7):e29026. doi: 10.1002/pbc.29026. Epub 2021 Mar 22.

Authors

Michael P Triebwasser^{1

2}, David M Barrett^{1

2

3}, Hamid Bassiri^{2

3

4}, Nancy Bunin^{1

2

3}, Caitlin Elgarten^{1

2

3}, Jason Freedman^{1

2}, Abdallah S Geera⁵, Dimitri Monos^{6

7}, Michele P Lambert^{2

3

8}, Timothy Olson^{1

2}, Alix E Seif^{1

3}, Michele Paessler^{3

6

7}, Whitney Petrosa³, Anne F Reilly^{1

2

3}, Neil Romberg^{2

3

9}, Kathleen E Sullivan^{2

3

9}, Ghazal Z Quinn⁵, Edward Behrens^{2

3

10}, David T Teachey^{1

2

3}

Affiliations

¹ Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
² Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
³ Immune Dysregulation Frontier Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁴ Division of Infectious Disease, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁵ Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶ Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁷ Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁸ Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
⁹ Division of Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
¹⁰ Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Antibodies, Monoclonal / therapeutic use
Antibodies, Neutralizing / therapeutic use
Drug Combinations
Humans
Lymphohistiocytosis, Hemophagocytic* / drug therapy
Nitriles / therapeutic use
Pyrazoles / therapeutic use
Pyrimidines / therapeutic use

Substances

Antibodies, Monoclonal
Antibodies, Neutralizing
Drug Combinations
Emapalumab
Nitriles
Pyrazoles
Pyrimidines
ruxolitinib

Publication types

MeSH terms

Substances

Grants and funding