Abstract
Tsukushi (TSK), a newly identified hepatokine, is a member of the small leucine-rich proteoglycans (SLRPs) family. TSK was originally isolated and identified in the lens of the chicken. Preliminary research on TSK has focused on its role in various physiological processes such as growth and development, wound healing, and cartilage formation. In recent years, the role of TSK in regulating cell signaling pathways, cell proliferation, and differentiation has been studied. In addition, the research has gradually expanded to the fields of glycolipid metabolism and energy balance. This article briefly reviews the role of TSK in the physiological and pathological process.
Keywords:
Tsukushi (TSK); metabolism; signaling pathways; tumorigenesis.
© 2021 International Union of Biochemistry and Molecular Biology.
MeSH terms
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Animals
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Carcinogenesis / genetics*
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Carcinogenesis / metabolism
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Carcinogenesis / pathology
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Cartilage / cytology
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Cartilage / metabolism
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Cell Differentiation
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Cell Line, Tumor
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Cell Proliferation
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Energy Metabolism / genetics
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Extracellular Matrix / metabolism*
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Extracellular Matrix / pathology
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Gene Expression Regulation, Developmental
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Humans
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Intercellular Signaling Peptides and Proteins / genetics*
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Intercellular Signaling Peptides and Proteins / metabolism
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Non-alcoholic Fatty Liver Disease / genetics*
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Non-alcoholic Fatty Liver Disease / metabolism
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Non-alcoholic Fatty Liver Disease / pathology
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Proteoglycans / genetics*
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Proteoglycans / metabolism
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Signal Transduction / genetics*
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Smad Proteins / genetics
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Smad Proteins / metabolism
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Wound Healing / genetics
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beta Catenin / genetics
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beta Catenin / metabolism
Substances
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CTNNB1 protein, human
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Intercellular Signaling Peptides and Proteins
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Proteoglycans
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Smad Proteins
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TSKU protein, human
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beta Catenin