Successful treatment of IgG4-related hypertrophic pachymeningitis with induction rituximab and dexamethasone followed by maintenance rituximab

Karan Seegobin; Muhamad A Moustafa; Nicole Gannon; Katelyn Keller; Jacquelyn Hastings; Vivek Gupta; Han W Tun; Liuyan Jiang

doi:10.1002/ccr3.3855

Successful treatment of IgG4-related hypertrophic pachymeningitis with induction rituximab and dexamethasone followed by maintenance rituximab

Clin Case Rep. 2021 Jan 27;9(3):1610-1614. doi: 10.1002/ccr3.3855. eCollection 2021 Mar.

Authors

Karan Seegobin¹, Muhamad A Moustafa¹, Nicole Gannon¹, Katelyn Keller¹, Jacquelyn Hastings¹, Vivek Gupta², Han W Tun¹, Liuyan Jiang³

Affiliations

¹ Division of Haematology and Medical Oncology Mayo Clinic Jacksonville Florida Jacksonville FL USA.
² Department of Radiology Mayo Clinic Jacksonville Florida Jacksonville FL USA.
³ Department of Pathology Mayo Clinic Jacksonville Florida Jacksonville FL USA.

Abstract

IgG4-related disease (IgG4RD) with intracranial involvement is rare. We report a 56-year-old male who had an excellent response to rituximab and dexamethasone after going undiagnosed for 5 years. After 3 years of rituximab maintenance, he has no evidence of disease on brain MRI.

Keywords: IgG4 disease; headache; lymphoproliferative disorder; maintenance rituximab; pachymeningitis.

Publication types

Case Reports