Gain of 'FAOnction', Loss of Fibrosis

Rebekah J Nicholson; Nirupama Ramkumar; Scott A Summers

doi:10.1016/j.tem.2021.03.005

Gain of 'FAOnction', Loss of Fibrosis

Trends Endocrinol Metab. 2021 Jun;32(6):333-334. doi: 10.1016/j.tem.2021.03.005. Epub 2021 Mar 24.

Authors

Rebekah J Nicholson¹, Nirupama Ramkumar², Scott A Summers³

Affiliations

¹ Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
² Division of Nephrology and Hypertension, University of Utah Health Center, Salt Lake City, UT, USA.
³ Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA. Electronic address: [email protected].

Abstract

Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiration, mitochondrial dynamics, and tubular epithelial cell (TEC) differentiation, while upregulation of FAO in kidney tubules provided protection from kidney fibrosis and functional decline.

Keywords: chronic kidney disease; fatty acid oxidation; kidney fibrosis; tubular epithelial cell.

MeSH terms

Animals
Disease Models, Animal*
Fibrosis
Gain of Function Mutation
Kidney Diseases*
Lipid Metabolism*
Mice

Abstract

MeSH terms

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