Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP

Gordon F Buchanan; Bruce J Gluckman; Franck K Kalume; Samden Lhatoo; Rama K Maganti; Jeffrey L Noebels; Kristina A Simeone; Mark S Quigg; Milena K Pavlova

doi:10.1177/15357597211004556

Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP

Epilepsy Curr. 2021 Mar 31;21(3):15357597211004556. doi: 10.1177/15357597211004556. Online ahead of print.

Authors

Gordon F Buchanan¹, Bruce J Gluckman^{2

3

4}, Franck K Kalume⁵, Samden Lhatoo⁶, Rama K Maganti⁷, Jeffrey L Noebels^{8

9

10}, Kristina A Simeone¹¹, Mark S Quigg¹², Milena K Pavlova¹³

Affiliations

¹ Department of Neurology and Iowa Neuroscience Institute, 12243University of Iowa Carver College of Medicine, Iowa City, IA, USA.
² Department of Engineering Science & Mechanics, 8082Penn State University, University Park, PA, USA.
³ Department of Neurosurgery, 8082Penn State University, University Park, PA, USA.
⁴ Department of Biomedical Engineering, 8082Penn State University, University Park, PA, USA.
⁵ Department of Neurological Surgery, University of Washington and 145793Seattle Children's Research Institute, Seattle, WA, USA.
⁶ Department of Neurology, 12339University of Texas McGovern Medical School, Houston, TX, USA.
⁷ Department of Neurology, 5228University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁸ Department of Neurology, 3989Baylor College of Medicine, Houston, TX, USA.
⁹ Department of Neuroscience, 3989Baylor College of Medicine, Houston, TX, USA.
¹⁰ Department of Molecular & Human Genetics, 3989Baylor College of Medicine, Houston, TX, USA.
¹¹ Department of Pharmacology & Neuroscience, 12282Creighton University School of Medicine, Omaha, NE, USA.
¹² Department of Neurology, 12350University of Virginia School of Medicine, Charlottesville, VA, USA.
¹³ Department of Neurology, 1861Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Abstract

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.

Keywords: SUDEP; comorbidities; dysregulation; epilepsy; pathophysiological mechanisms; sleep.

Grants and funding

R01 NS102796/NS/NINDS NIH HHS/United States