HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e338-e353. doi: 10.1161/ATVBAHA.121.315933. Epub 2021 Apr 1.

Abstract

[Figure: see text].

Keywords: HSP27 heat-shock proteins; atherosclerosis; cholesterol; inflammation; proprotein convertases; receptors, LDL; vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Animals
  • Antibodies / blood
  • Aorta / drug effects*
  • Aorta / enzymology
  • Aorta / immunology
  • Aorta / pathology
  • Aortic Diseases / enzymology
  • Aortic Diseases / immunology
  • Aortic Diseases / pathology
  • Aortic Diseases / prevention & control*
  • Atherosclerosis / enzymology
  • Atherosclerosis / immunology
  • Atherosclerosis / pathology
  • Atherosclerosis / prevention & control*
  • Case-Control Studies
  • Cholesterol / metabolism*
  • Disease Models, Animal
  • Female
  • Heat-Shock Proteins / administration & dosage*
  • Heat-Shock Proteins / immunology
  • Heat-Shock Proteins / metabolism
  • Hep G2 Cells
  • Humans
  • Immunogenicity, Vaccine
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout, ApoE
  • Middle Aged
  • Molecular Chaperones / administration & dosage*
  • Molecular Chaperones / immunology
  • Molecular Chaperones / metabolism
  • Plaque, Atherosclerotic
  • Proprotein Convertase 9 / metabolism*
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism*
  • Vaccination
  • Vaccines, Synthetic / administration & dosage*
  • Vaccines, Synthetic / immunology

Substances

  • Antibodies
  • HSPB1 protein, human
  • Heat-Shock Proteins
  • Hsbp1 protein, mouse
  • Molecular Chaperones
  • Receptors, LDL
  • Vaccines, Synthetic
  • Cholesterol
  • Pcsk9 protein, mouse
  • Proprotein Convertase 9