Concordance of a High Polygenic Score Among Relatives: Implications for Genetic Counseling and Cascade Screening

Circ Genom Precis Med. 2021 Apr;14(2):e003262. doi: 10.1161/CIRCGEN.120.003262. Epub 2021 Apr 2.

Authors

Nicholas J Reid^{1

2}, Deanna G Brockman^{3

1}, Courtney Elisabeth Leonard^{3

1}, Renee Pelletier^{3

1}, Amit V Khera^{3

1

2}

Affiliations

¹ Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (N.J.R., D.G.B., C.E.L., R.P., A.V.K.).
² Harvard Medical School, Boston, MA (N.J.R., A.V.K.).
³ Department of Medicine, Harvard Medical School, Center for Genomic Medicine and Division of Cardiology, Massachusetts General Hospital, Boston (D.G.B., C.E.L., R.P., A.V.K.).

No abstract available

Keywords: cognition; genetics; humans; obesity; phenotype.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Atrial Fibrillation / genetics
Atrial Fibrillation / pathology
Coronary Artery Disease / genetics
Coronary Artery Disease / pathology
Diabetes Mellitus / genetics
Diabetes Mellitus / pathology
Family
Genetic Counseling*
Genetic Testing*
Genome-Wide Association Study
Humans
Risk Factors

Grants and funding

K08 HG010155/HG/NHGRI NIH HHS/United States