Liposomal Encapsulation of Carvacrol to Obtain Active Poly (Vinyl Alcohol) Films

Molecules. 2021 Mar 13;26(6):1589. doi: 10.3390/molecules26061589.

Abstract

Lecithins of different origins and compositions were used for the liposomal encapsulation of carvacrol within the framework of the development of active films for food packaging. Liposomes were incorporated into aqueous polymeric solutions from fully (F) and partially (P) hydrolysed Poly (vinyl alcohol) (PVA) to obtain the films by casting. The particle size distribution and ζ-potential of the liposomal suspensions, as well as their stability over time, were evaluated. Liposomal stability during film formation was analysed through the carvacrol retention in the dried film and the film microstructure. Subtle variations in the size distributions of liposomes from different lecithins were observed. However, the absolute values of the ζ-potential were higher (-52, -57 mV) for soy lecithin (SL) liposomes, followed by those of soy lecithin enriched with phosphatidylcholine (SL-PC) (-43, -50 mV) and sunflower lecithin (SFL) (-33, -38 mV). No significant changes in the liposomal properties were observed during the study period. Lyotropic mesomorphism of lipid associations and carvacrol leakage occurred to differing extents during the film drying step, depending on the membrane lipid composition and surface charge. Liposomes obtained with SL-PC were the most effective at maintaining the stability of carvacrol emulsion during film formation, which led to the greatest carvacrol retention in the films, whereas SFL gave rise to the least stable system and the highest carvacrol losses. P-PVA was less sensitive to the emulsion destabilisation due to its greater bonding capacity with carvacrol. Therefore, P-PVA with carvacrol-loaded SL-PC liposomes has great potential to produce active films for food packaging applications.

Keywords: food packaging; fully hydrolysed PVA; lyotropic mesomorphism: phosphatidylcholine; partially hydrolysed PVA.

MeSH terms

  • Anti-Infective Agents / administration & dosage
  • Antioxidants / administration & dosage
  • Biodegradable Plastics / chemistry
  • Cymenes / administration & dosage*
  • Drug Compounding / methods
  • Drug Stability
  • Emulsions
  • Food Packaging / methods*
  • Food Preservation / methods
  • Humans
  • Lecithins / chemistry
  • Liposomes / chemistry*
  • Liposomes / ultrastructure
  • Microscopy, Electron, Scanning
  • Particle Size
  • Polyvinyl Alcohol / chemistry*

Substances

  • Anti-Infective Agents
  • Antioxidants
  • Biodegradable Plastics
  • Cymenes
  • Emulsions
  • Lecithins
  • Liposomes
  • Polyvinyl Alcohol
  • carvacrol