8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation

Andreas H Groll; Dorothea Pana; Fanny Lanternier; Alessio Mesini; Roland A Ammann; Dina Averbuch; Elio Castagnola; Simone Cesaro; Dan Engelhard; Carolina Garcia-Vidal; Jukka Kanerva; Nicole Ritz; Emmanuel Roilides; Jan Styczynski; Adilia Warris; Thomas Lehrnbecher; 8th European Conference on Infections in Leukaemia

doi:10.1016/S1470-2045(20)30723-3

8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation

Lancet Oncol. 2021 Jun;22(6):e254-e269. doi: 10.1016/S1470-2045(20)30723-3. Epub 2021 Mar 31.

Authors

Andreas H Groll¹, Dorothea Pana², Fanny Lanternier³, Alessio Mesini⁴, Roland A Ammann⁵, Dina Averbuch⁶, Elio Castagnola⁴, Simone Cesaro⁷, Dan Engelhard⁶, Carolina Garcia-Vidal⁸, Jukka Kanerva⁹, Nicole Ritz¹⁰, Emmanuel Roilides¹¹, Jan Styczynski¹², Adilia Warris¹³, Thomas Lehrnbecher¹⁴; 8th European Conference on Infections in Leukaemia

Affiliations

¹ Infectious Disease Research Program, Center for Bone Marrow Transplantation, and Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany. Electronic address: [email protected].
² Department of Medicine, European University of Cyprus, Nicosia, Cyprus.
³ Infectious Diseases Unit, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, Paris, France.
⁴ Infectious Diseases Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
⁵ Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, Bern, Switzerland.
⁶ Department of Pediatrics, Hebrew University Medical Center, Jerusalem, Israel.
⁷ Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
⁸ Department of Infectious Diseases, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; IDIBAPS, University of Barcelona, Barcelona, Spain.
⁹ Division of Hematology-Oncology and Stem Cell Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
¹⁰ Pediatric Infectious Diseases and Vaccinology, University of Basel Children's Hospital, Basel, Switzerland.
¹¹ Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Health Sciences, and Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹² Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.
¹³ MRC Centre for Medical Mycology, University of Exeter, Exeter, UK; Great Ormond Street Hospital London, London, UK.
¹⁴ Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe University, Frankfurt, Germany.

PMID: 33811813
DOI: 10.1016/S1470-2045(20)30723-3

Abstract

Paediatric patients with cancer and those undergoing allogeneic haematopoietic cell transplantation have an increased susceptibility to invasive fungal diseases. In addition to differences in underlying conditions and comorbidities relative to adults, invasive fungal diseases in infants, children, and adolescents are unique in terms of their epidemiology, the validity of current diagnostic methods, the pharmacology and dosing of antifungal agents, and the absence of phase 3 clinical trials to provide data to guide evidence-based interventions. To re-examine the state of knowledge and to further improve invasive fungal disease diagnosis, prevention, and management, the 8th European Conference on Infections in Leukaemia (ECIL-8) reconvened a Paediatric Group to review the literature and to formulate updated recommendations according to the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and European Confederation of Medical Mycology (ECMM) grading system, which are summarised in this Review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antifungal Agents / therapeutic use
Congresses as Topic
Guidelines as Topic
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Leukemia / complications
Leukemia / epidemiology
Leukemia / microbiology
Leukemia / therapy*
Mycoses / complications
Mycoses / epidemiology
Mycoses / microbiology
Mycoses / therapy*
Pediatrics / trends

Substances

Antifungal Agents