H3K4 Methyltransferase Smyd3 Mediates Vascular Smooth Muscle Cell Proliferation, Migration, and Neointima Formation

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1901-1914. doi: 10.1161/ATVBAHA.121.314689. Epub 2021 Apr 8.

Di Yang^{1

2}, Zhenghua Su¹, Gang Wei³, Fen Long¹, Yi-Chun Zhu⁴, Ting Ni³, Xinhua Liu¹, Yi Zhun Zhu²

¹ Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, 201203 P.R. China (D.Y., Z.H.S., F.L., X.H.L.).
² State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, China (D.Y., Y.Z.Z.).
³ State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, 200438 P.R. China (G.W., T.N.).
⁴ Shanghai Key Laboratory of Bioactive Small Molecules and Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China (Y.C.Z.).

Abstract

[Figure: see text].

Keywords: Smyd3; cell proliferation; histones; hyperplasia; neointima; vascular remodeling.